A0908
Title: Comorbidity patterns and temporal associations of multiple long-term conditions in adults with intellectual disability
Authors: Georgina Cosma - Loughborough University (United Kingdom) [presenting]
Abstract: Multiple long-term conditions (MLTCs), defined as the presence of two or more chronic health conditions, pose significant challenges for healthcare systems, particularly for vulnerable populations such as individuals with intellectual disability. The distribution, temporal associations, and age/sex-specific patterns of MLTCs are statistically examined in adults with intellectual disability using longitudinal healthcare data. The 18,144 adults with intellectual disability (10,168 males and 7,976 females) are analysed and identified in the Clinical Practice Research Datalink, linked to Hospital Episode Statistics data (2000-2021). Temporal statistical analysis established directional associations among 40 long-term conditions, stratified by sex and age groups (under 45, 45-64, 65+). The high prevalence of enduring mental illness across all age groups distinguished this population from the general population. In males, mental illness co-occurred with gastrointestinal conditions, while in females, mental illness presented alongside chronic pain and endocrine conditions. Findings highlight complex sex-specific MLTC patterns across age groups, revealing temporal associations that provide insights into disease progression, informing targeted prevention strategies and interventions to prevent premature mortality in this vulnerable population.
