A0754
Title: Effect sizes variability in harmonization studies of Alzheimer's disease biomarkers
Authors: Dana Tudorascu - University of Pittsburgh (United States) [presenting]
Abstract: In recent years, multisite neuroimaging and blood biomarkers studies of Alzheimer's Disease have been rising in popularity due to increased statistical power and enabling the generalization of research outcomes; however, different blood biomarkers collection as well as summary neuroimaging measures derived from Positron Emission Tomography (PET) studies using different tracers and scanners, hinders the direct comparability of these measures across different sites. Furthermore, differences between these measures can lead to high variability in estimating effect sizes across clinical groups, depending on the blood assay, imaging scanner, or PET imaging tracer used. The aim is to present several standardization methods for blood biomarkers and for PET imaging-derived measures across different sites or scanners and to show effect-size variability in clinical groups using different harmonization techniques.
