A1972
Title: Joint accelerated rate and hazard model for recurrent events and informative terminals
Authors: Chuan-Fa Tang - University of Texas at Dallas (United States) [presenting]
Sy Han Chiou - Southern Methodist University (United States)
Weixi Zhu - UT Southwestern Medical Center (United States)
Abstract: Recurrent and terminal events are commonly observed and often correlated in longitudinal studies. A joint accelerated rate and hazard modeling framework is proposed that simultaneously accommodates recurrent events and an informative terminal event via subject-specific frailty. A rank-based estimation procedure is employed. A perturbation-based approach is refined for estimating the variance-covariance matrix, and Wald and score tests are developed for statistical inference. The proposed methods are supported through numerical studies and illustrated using real-world colorectal cancer datasets.
