A1866
Title: TxMicroSim: A web-based app for multi-stage treatment decision making
Authors: Xuelin Huang - University of Texas MD Anderson Cancer Center (United States) [presenting]
Abstract: Multistate disease progression complicates the comparison of treatment strategies, motivating the development of a user-friendly web tool for multistate disease progression simulation and treatment decision support. Microsimulation is a natural approach for identifying optimal treatment strategy. The framework employs microsimulation using a multistate model to capture state-to-state transition hazards. TxMicroSim is a web-based interface built with R Shiny to determine the optimal strategy of sequential treatment by comparing restricted mean survival times (RMST) under alternative treatment strategies. The application consists of three main steps: defining the multistate structure, building the multistate model, and performing microsimulation. Throughout the app, interactive visualizations are provided for the multistate structure, estimated hazard ratios and baseline hazards, and RMST comparisons across treatment strategies.
