Title: Understand cancer natural history from cancer screening trials
Authors: Yu Shen - UT MD Anderson Cancer Center (United States) [presenting]
Abstract: The primary objective of screening is to detect a cancer in the preclinical state with the expectation that earlier diagnosis together with effective treatment will yield longer survival or cure. Over last decades, many of cancer screening studies have been conducted for breast, lung, colon and prostate. These trials generate data, which may be used to estimate the preclinical sojourn time distribution and screening sensitivity and other quantities of interest from the screening cohort. The information on the natural history of cancer is critical in designing optimal screening programs and assessing screening benefit. We will review some existing parametric and nonparametric approaches in this area.