A0332
Title: Mapping individual differences in inter-modal coupling
Authors: Sarah Weinstein - Temple University (United States) [presenting]
Abstract: Within-individual "coupling" between measures of brain structure and function evolves in development and may underlie differential risk for neuropsychiatric disorders. Despite increasing interest in the development of structure-function relationships, rigorous methods to quantify and test individual differences in coupling remain nascent. The purpose is to explore and address gaps in approaches for testing and spatially localizing individual differences in intermodal coupling. A new method, called CIDeR, is proposed and designed to simultaneously perform hypothesis testing in a way that limits false positive results and improves the detection of true positives. Through a comparison with existing approaches to quantifying and testing individual differences in coupling, subtle differences are delineated in their underlying null hypotheses, which may ultimately lead researchers to arrive at different results. Finally, the utility of CIDeR is illustrated in two applications to data from a large-scale study of neurodevelopment.
