A1645
Title: Using tissue-specific genetic variation in Mendelian randomization
Authors: Ryan Liu - University of Pennsylvania (United States)
Chong Jin - New Jersey Institute of Technology (United States) [presenting]
Qi Long - University of Pennsylvania (United States)
Abstract: Studies have shown that intelligence is negatively correlated with Alzheimer's disease risk. However, the causality between tissue-mediated intelligence and Alzheimer's disease risk remains unclear. In addition, the tissue-related molecular pathways that mediate the effect of intelligence on Alzheimer's disease risk remain unclear. A two-sample multivariable Mendelian randomization study is conducted to analyze how tissue-specific gene expression mediates the effect of intelligence on Alzheimer's disease risk. Evidence that educational attainment independently affected Alzheimer's disease risk when analyzed with intelligence was not revealed. However, tissue-specific expression-mediated intelligence was associated with Alzheimer's disease risk independently from educational attainment with a log odds ratio of -1.59 (95\% CI: -2.73, -0.443; p = 6.5710-3). The aim is to provide evidence supporting a causal association between tissue-specific gene expressions and the effect of intelligence on Alzheimer's Disease risk. Specifically, genes associated with intelligence located in brain tissues were found to be negatively correlated with Alzheimer's disease risk.
