A1166
Title: Computationally efficient approach to operational prior specification for phase I dose-escalation trials
Authors: Pavel Mozgunov - University of Cambridge (United Kingdom) [presenting]
Abstract: Recent years have seen increased interest in combining drug agents and schedules. Several methods for Phase I combination-escalation trials have been proposed. Most of these designs require specifying many hyper-parameters, often chosen from statistical considerations (operational prior). The conventional "grid search'' calibration approach requires large simulations, which are computationally costly. A novel "cyclic calibration" has been proposed to reduce the computation from multiplicative to additive. Furthermore, calibration processes should consider a wide range of scenarios of true toxicity probabilities to avoid bias. A method to reduce scenarios based on scenario complexities is suggested. This can reduce the computation by more than 500 folds while maintaining operational characteristics similar to the grid search.
