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B0476
Title: Adaptive lasso for the Cox regression with interval censored and possibly left truncated data Authors:  Chenxi Li - Michigan State University (United States) [presenting]
Daewoo Pak - The University of Texas MD Anderson Cancer Center (United States)
David Todem - Michigan State University (United States)
Abstract: A penalized variable selection method is proposed for the Cox proportional hazards model with interval censored data. A penalized nonparametric maximum likelihood estimation is conducted with an adaptive lasso penalty, which can be implemented through a penalized EM algorithm. The method is proven to enjoy the desirable oracle property. We also extend the method to left truncated and interval censored data. Our simulation studies show that the method possesses the oracle property in samples of modest sizes and outperforms available existing approaches in many of the operating characteristics. An application to a dental caries data set illustrates the method's utility.