Title: Semiparametric nonlinear mixed-effects PK/PD modelling under misspecification
Authors: Dae-Jin Lee - BCAM - Basque Center for Applied Mathematics (Spain) [presenting]
Abstract: Mathematical and statistical modelling has become an important tool in the development of new medical drugs, since it may help to understand the outcome of clinical trials. The scientific disciplines concerning mathematical modelling in drug development are called pharmacokinetics and pharmacodynamics (PK/PD). We present an extension of a previous work to address a potential structural model misspecification for population in PK/PD analysis via based on penalized splines. We illustrate our approach with data from a study of the kinetics of the anti-asthmatic drug (theophylline).