A0285
Title: Borrow dose-response information from an historical experiment in aquatic toxicity assessment
Authors: Jing Zhang - Miami University (United States) [presenting]
Shixuan Wang - University of Cincinnati (United States)
Bin Zhang - Cincinnati Children's Hospital Medical Center (United States)
Abstract: Aquatic toxicity tests assess the negative impact of toxicants on the survival, reproduction, and growth of organisms. Since such tests are often repeated periodically in the same lab, borrowing historical experimental outcomes that are congruent would increase the precision in potency estimation. Historical borrowing has been a popular research topic, especially in clinical trials. An existing Bayesian historical borrowing technique, calibrated power prior (CPP), is extended to borrow dose-response information from a historical experiment with a modified calibration algorithm in aquatic toxicity assessment. The effectiveness and flexibility of the proposed method are demonstrated via simulation studies. An application to the Ceriodaphnia dubia reproduction test is presented.
