A0211
Title: Graphical approaches and reverse graphical approaches in clinical studies with multiple endpoints
Authors: Jiangtao Gou - Villanova University (United States) [presenting]
Abstract: Multiple test problems in clinical trials are common and diverse. The graphical approach has been proposed as a general framework for clinical trial designs with multiple hypotheses, where decisions are based on the observed marginal p values. It begins with a graph comprising all hypotheses as vertices, then progressively removes vertices when their corresponding hypotheses are rejected. In contrast, the reverse graphical approach starts with singleton graphs and incrementally adds vertices until a hypothesis set is rejected. Some properties of the reverse graphical approach are further evaluated and discussed.
