A0894
Title: Longitudinal causal analysis of HIV antiretroviral therapy effects on weight gain
Authors: Andrew Spieker - Vanderbilt University Medical Center (United States) [presenting]
Abstract: Prior studies have examined the effects of various antiretroviral therapy regimens and their impacts on subsequent weight gain in persons living with HIV cross-sectionally. However, large observational cohorts of persons living with HIV often feature antiretroviral treatment trajectories that are unstable over time. Traditional approaches to analyzing longitudinal causal effects can sometimes be criticized for over-reliance on stringent parametric assumptions. A flexible semi-parametric approach based on cumulative probability models examines the longitudinal effects of core and ancillary agents comprising antiretroviral therapies on weight gain in a large cohort of persons living with HIV. More robust evidence supports the hypothesis that modern integrase strand transfer inhibitors and tenofovir alafenamide are associated with greater mean weight gain than other core and ancillary antiretroviral agents.
