A0262
Title: Interpretable discriminant analysis for functional data supported on random non-linear domains
Authors: Eardi Lila - University of Washington (United States) [presenting]
Abstract: A novel framework for the classification of functional data supported on non-linear and possibly random manifold domains is introduced. The motivating application is the identification of subjects with Alzheimer's disease from their cortical surface geometry and associated cortical thickness map. The proposed model is based upon a reformulation of the classification problem as a regularized multivariate functional linear regression model. This allows us to adopt a direct approach to the estimation of the most discriminant direction while controlling for its complexity with appropriate differential regularization. The proposed method is applied to a pooled dataset from the Alzheimer's Disease Neuroimaging Initiative and the Parkinson's Progression Markers Initiative and is able to estimate discriminant directions that capture both cortical geometric and thickness predictive features of Alzheimer's Disease.
