A0222
Title: Generating optimal order-of-addition two-level factorial designs
Authors: Shin-Fu Tsai - National Taiwan University (Taiwan) [presenting]
Abstract: In many industrial and scientific studies, efficient experimental designs can extract as much information as possible from the observed data under resource constraints. This study will introduce a new class of optimal designs for order-of-addition two-level factorial experiments in which both component addition orders and component levels can be varied over treatments. The proposed designs can be generated by combining order-of-addition orthogonal arrays and two-level orthogonal arrays. Therefore, pairwise order effects and component main effects can be estimated with optimal efficiency. Several construction methods will be introduced to generate these kinds of optimal designs. A drug combination study will also be presented to show that the proposed designs can be practical for real-world studies.
