A0176
Title: Beyond ComBat: Next-generation harmonization methods for multi-centre neuroimaging studies
Authors: Russell Shinohara - University of Pennsylvania (United States) [presenting]
Abstract: Magnetic resonance imaging (MRI) studies often involve large multi-centre designs. To address this, an increasingly commonly used approach is ComBat, which was first proposed in the genomics literature. Our group has found these methods helpful but sometimes insufficient in complex study designs, mainly when employing joint or predictive modelling. To address this, a broader framework has been developed for multi-scanner harmonization, allowing for flexible, non-linear, and multivariate modelling in various imaging science settings.
