A1295
Title: Imaging mediation analysis for longitudinal outcomes
Authors: Cai Li - St. Jude Children's Research Hospital (United States) [presenting]
Abstract: The focus is improving cognitive outcomes for pediatric cancer survivors undergoing aggressive cancer treatments that may affect the central nervous system. Specifically, a new mediation model is proposed for longitudinal outcomes to a clinical trial for medulloblastoma, using high-dimensional imaging mediators to identify causal pathways and corresponding white matter microstructures. The proposed approach accounts for spatial dependency and smoothness of the mediators, improving the detection power of informative voxels. The results provide guidance on improving long-term neurodevelopment and sparing brain regions impacted by treatment. The validity of the method is confirmed through simulation studies.
