A0372
Title: Multimodal neuroimaging data integration and pathway analysis
Authors: Yi Zhao - Indiana University (United States) [presenting]
Lexin Li - University of California Berkeley (United States)
Brian Caffo - Johns Hopkins University (United States)
Abstract: With fast advancements in technologies, collecting multiple types of measurements on a common set of subjects is becoming routine in science. Some notable examples include multi-modal neuroimaging studies for the simultaneous investigation of brain structure and function and multi-omics studies for combining genetic and genomic information. Integrative analysis of multimodal data allows scientists to interrogate new mechanistic questions. However, the data collection and generation of integrative hypotheses is outpacing available methodology for joint analysis of multimodal measurements. We study high-dimensional multimodal data integration in the context of mediation analysis. We aim to understand the roles different data modalities play as possible mediators in the pathway between an exposure variable and an outcome. We propose a mediation model framework with two data types serving as separate sets of mediators and develop a penalized optimization approach for parameter estimation. We study both the theoretical properties of the estimator through an asymptotic analysis and its finite-sample performance through simulations. We illustrate our method with a multimodal brain pathway analysis with structural and functional connectivities as mediators in the association between sex and language processing.
