B0538
Title: Structure-function gradients along the brain cortex
Authors: Andrew Chen - University of Pennsylvania (United States) [presenting]
Abstract: Recent methodological advances allow examining the topological organization of the brain cortex and deriving gradients of organization. These gradients are consistent with seminal research on brain functional organization, well-studied neurodevelopmental trajectories, and measures of association between structural and functional measures. This structure-function relationship has attracted particular interest due to its association with known biological changes. However, gradients have generally been estimated solely through functional imaging and have yet to capture structural trends in the brain. A novel method is proposed for the derivation of structure-function gradients from both functional magnetic resonance imaging and diffusion tensor imaging. Application to the Philadelphia Neurodevelopmental Cohort reveals that these novel gradients reflect well-known brain organization while suggesting novel cortical patterns. The method extends more generally to any multimodal brain measurements and potential extensions and statistical frameworks are explored for downstream analyses.
