B1415
Title: Heritability estimation with similarity decoding
Authors: Jianqiao Wang - Harvard University (United States) [presenting]
Abstract: The heritability estimation is considered. Previous linear fixed-effect and random-effect modelling performance is sensitive to their assumptions of regression coefficients and the design matrix. These linear model assumptions are non-necessarily restrictive. A general variance component modelling framework is proposed under weaker conditions. A robust heritability estimation is developed to address the dependency between the genetic effects and the genotype distribution under the negative selection.
