B1398
Title: Trial sequential analysis: Application to N-of-1 designs
Authors: Rebecca Betensky - New York University (United States) [presenting]
Shu Jiang - Washington university (United States)
Abstract: Trial sequential analysis was proposed 25 years ago to allow for the rigorous conduct of cumulative meta-analyses. As new studies were published, they were added to the accumulating set of studies and analyzed jointly. This framework is considered for the conduct of multiple N-of-1 studies and specifications of the appropriate null and alternative hypotheses are discussed. An important distinction is that the results of each constituent study are meaningful for the particular individual under study, while the conglomerate of studies is meaningful for the population.
