B1213
Title: Investigating microbiome-metabolome-clinical pathways using multiview microbiome data
Authors: Yue Wang - University of Colorado Anschutz Medical Campus (United States) [presenting]
Abstract: Modern microbiome studies often involve multi-omics data collected from multiple sites. New statistical methods are needed to integrate these data sets effectively and to attain new scientific insights into host-microbiome associations. A novel structural equation model is discussed that identifies causal pathways among microbiome, metabolome, and phenotype data. This model will also identify four different roles of the microbes, facilitating the understanding of host-microbiome associations. The effectiveness of the proposed model is demonstrated through an application where IBD-associated microbial pathways are investigated.
