B1058
Title: Variant component test for cell-type-aware analysis of RNA-seq data
Authors: Chong Jin - New Jersey Institute of Technology (United States) [presenting]
Abstract: Bulk tissues are heterogeneous mixtures of multiple cell types. A cell-type-aware workflow for bulk RNA-seq data enables the discovery of variation in cell-type-specific expression across conditions. However, the sensitivity of such discovery suffers as the number of cell types in the model increases. A framework is presented for integrating multiple cell types into a variant component test to increase the power of detecting global changes in cell-type-specific expression across conditions. Simulations and real data examples are used in neurological disorders to illustrate the proposed method.
