B1457
Title: Nonconvex-regularized integrative sufficient dimension reduction for multi-source Data
Authors: Wei Qian - University of Delaware (United States) [presenting]
Shanshan Ding - University of Delaware (United States)
Abstract: As advances in high-throughput technology significantly expand data availability, integrative analysis of multiple data sources has become an increasingly important tool for biomedical studies. We propose an integrative and nonconvex-regularized sufficient dimension reduction method to achieve simultaneous dimension reduction and variable selection for multi-source data analysis in high dimensions. The proposed method aims to extract sufficient information in a supervised fashion, and our asymptotic results establish new theory for integrative sufficient dimension reduction and allow the number of predictors in each data source to increase exponentially fast with sample size. The promising performance of the integrative estimator and efficient numerical algorithms is demonstrated through simulation and multi-omics breast cancer data analysis.
