B0795
Title: A functional data approach to heterogeneous aging effects on functional connectivity
Authors: Jeng-Min Chiou - Academia Sinica (Taiwan) [presenting]
Abstract: The normal aging effects on the cerebral cortex are investigated by characterizing changes in functional connectivity using resting-state fMRI data. We proposed a functional correlation coefficient for measuring functional connectivity, which takes into account dependency between different brain regions. The distinct patterns of changes in functional connectivity within and among the cerebral lobes clarified the effects of normal aging on cortical function. The results showed heterogeneous changes in functional connectivity in normal aging and supported the frontal aging hypothesis proposed in behavioral and structural MRI studies. The functional correlation analysis enables differentiation of changes in function connectivity and characterizes the heterogeneous aging effects in different cortical regions.
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