B1211
Title: Efficient estimation of the Cox model with auxiliary subgroup survival information
Authors: Chiung-Yu Huang - Johns Hopkins University (United States) [presenting]
Jing Qin - National Institutes of Health (United States)
Huei-Ting Tsai - Georgetown University (United States)
Abstract: With the rapidly increasing availability of data in the public domain, combining information from different sources to infer about associations or differences of interest has become an emerging challenge to researchers. We present a novel approach to improve efficiency in estimating the survival time distribution by synthesizing information from the individual-level data with $t$-year survival probabilities from external sources such as disease registries. While disease registries provide accurate and reliable overall survival statistics for the disease population, critical pieces of information that influence both choice of treatment and clinical outcomes usually are not available in the registry database. To combine with the published information, we propose to summarize the external survival information via a system of nonlinear population moments and estimate the survival time model using empirical likelihood methods. The proposed approach is more flexible than the conventional meta-analysis in the sense that it can automatically combine survival information for different subgroups and the information may be derived from different studies. Moreover, an extended estimator that allows for a different baseline risk in the aggregate data is also studied. Simulation studies show that the proposed estimators yield a substantial gain in efficiency over the conventional partial likelihood approach.
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