B1547
Title: Orthogonal array composite designs for drug combination experiments with applications for tuberculosis
Authors: Jessica Jaynes - California State University Fullerton (United States) [presenting]
Abstract: The aim is to provide an overview of the orthogonal array composite design (OACD) methodology, show that they can be robust to missing data under practical scenarios and provide an application for tuberculosis. We compare the efficiencies of OACDs to the commonly used central composite designs (CCD) when there are a few missing observations and demonstrate that OACDs are more robust than the popular CCDs to missing observations for two scenarios. The first scenario assumes one observation is missing either from one factorial point or one additional point. The second scenario assumes two observations are missing either from two factorial points or from two additional points, or from one factorial point and one additional point. Two real-world applications of OACDs pertaining to tuberculosis are provided: a 155-run OACD with nine drugs and a 50-run OACD with six drugs.
